Cat No.
CEI-0997
Description
HNHA is a cell-permeable inhibitor of histone deacetylase (HDAC) activity. HNHA induces histone hyperacetylation and p21 transcription with inhibition of cell cycle progression in human fibrosarcoma HT1080 cells. In in vivo murine xenographs, HNHA is equally as effective as SAHA in inhibiting tumor growth. HNHA inhibits HUVEC growth and prevents tube formation and migration in response to VEGF. Also HNHA blocks retinal neovascularization and choroidal angiogenesis in mice.
Abbr
HNHA(HDAC9)
Alias
HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR
Synonyms
HD7, HD7b, HD9, HDAC, HDAC7, HDAC7B, HDAC9B, HDAC9FL, HDRP, MITR
CAS No.
926908-04-5
IC50
100 nM
Targets
HDAC
M.Wt
303.4
Purity
>98%
Appearance
A crystalline solid.
Storage
Store at or below -20 centigrade for up to two years.
