Cat No.
CEI-0524
Description
A synthetic broad-spectrum triazole antifungal agent with the mode of action being through Inhibition of cytochrome P450 dependent enzymes including 14α-demethylase. Recently, it has been shown that Itraconazole inhibits Hedgehog (Hh) signaling pathway activity (IC50 = 0.8 μM) as well as blocks the VEGFR2 glycosylation, trafficking, and signaling in endothelial cells.
Alias
Oriconazole, R51211, Sporanox
Synonyms
Oriconazole, R51211, Sporanox
CAS No.
84625-61-6
Product_Overview
An antifungal agent and Hh signaling inhibitor
Targets
Hh
Chemical Name
(2R,4S)-rel-1-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
M.Wt
489.99
Purity
>98% by HPLC
Appearance
Yellow solid
Solubility
DMSO (>20 mg/ml)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and moisture
Usage
For Research Use Only! Not For Use in Humans.
