Cat No.
CEI-0521
Description
Cell-permeable. A Hedgehog (Hh) signaling pathway antagonist. Inhibits Hh signaling downstream of Smo and Sufu at the level of Gli (IC50 = 5 μM). GANT61 has also been shown to inhibit the in vitro proliferation of PANC1 and 22Rv1 cells which have elevated GLi11 levels and prevent the development of 22Rv1 tumors in mice.
Alias
NSC 136476
Synonyms
NSC 136476
CAS No.
500579-04-4
Product_Overview
A Hedgehog (Hh) signaling pathway antagonist
Targets
Hh
Chemical Name
2,?2'-?[[dihydro-?2-?(4-?pyridinyl)-?1,?3(2H,?4H)-?pyrimidinediyl]bis(methylene)]bis(N,?N-?dimethyl-?benzenamine)
M.Wt
258.23
Purity
>98% by TLC
Appearance
White solid
Solubility
DMSO (5 mg/ml)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
