Cat No.
CEI-0520
Description
Cell-permeable. Acts as a blocker of Hedgehog (Hh) pathway downstream of SMO and SUFU causing Gli1 nuclear accumulation. It also targets Gli-mediated gene transactivation (IC50 ~ 5 μM in SAG-stimulated Shh-L2 cells) and displays anti-proliferative and antitumor activity in vivo.
Alias
NSC75503
Synonyms
NSC75503
CAS No.
64048-12-0
Product_Overview
A Hedgehog (Hh) signaling pathway inhibitor
Targets
Hh
Chemical Name
2,3,4,5-Tetra(4-pyridyl)thiophene
M.Wt
341.4
Purity
>98% by HPLC
Appearance
Off-white solid
Solubility
DMSO
Storage
-20 centigrade
Shipping Conditions
Gel Pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
