Cat No.
CEI-0214
Description
Ciproxifan can potently inhibit H3-receptor with IC50 of 9.2 nM.
CAS No.
184025-19-2
Targets
H3-receptor
Chemical Name
cyclopropyl-(4-(3-1H-imidazol-4-yl)propyloxy) phenyl) ketone
M.Wt
386.4
Purity
0.99
Solubility
DMSO 54 mg/ml, Water 1 mg/ml, Ethanol 54 mg/ml
Storage
2 years -20centigrade Powder
In vitro
Ciproxifan is a novel chemical series of histamine H3-receptor antagonist.Ciproxifan can potently inhibit H3-receptor with IC50 of 9.2 nM. In vitro, ciproxifan is a competitive antagonist at the H3 autoreceptor controlling [3H]histamine release from synaptosomes and displayed similar Ki values (0.5-1.9 nM) at the H3 receptor controlling the electrically-induced contraction of guinea pig ileum or at the brain H3 receptor labeled with [125I]iodoproxyfan. Ciproxifan displayed at least 3-orders of magnitude lower potency at various aminergic receptors studied in functional or binding tests.
