Cat No.
CEI-0334
Description
KW-2478
CAS No.
819812-04-9
Targets
HSP90
M.Wt
574.66
Purity
>99%
Solubility
No
Storage
2 years at -20 centigrade
In vitro
KW-2478 reduces the level of phosphorylated Erk1/2. KW-2478 induces apoptosis by cleavage of PARP, a substrate of caspase-3 In U266 cells,. KW-2478 has Time dependency of antiproliferative activity, consecutive drug exposure for at least 12 hours is necessary to to exert potent antitumor activity.KW-2478 also shows potent growth inhibitory activity in primary CLL and NHL cells with EC50 of 40-170 nM and 200-400 nM, respectively.
