Cat No.
CEI-0191
Description
AZD1480 can inihbit JAK1 and JAK2 with IC50 of 1.3 nM and 0.4 nM.
CAS No.
935666-88-9
Targets
JAK1, JAK2
Chemical Name
(S)-5-chloro-N2-(1-(5-fluoropyrimidin-2-yl)ethyl)-N4-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine
M.Wt
348.77
Purity
>99%
Solubility
DMSO 70 mg/mL Water
Storage
2 years at -20centigrade Powder
In vitro
AZD1480 is a novel pyrazol pyrimidine ATP-competitive inhibitor of JAK1 and JAK2 kinases, with IC50s of 1.3 and 0.4 nM. AZD1480 inhibits constitutive and IL-6 induced STAT-3 activation and subsequent nuclear translocation.
In vivo
AZD1480 shows inhibition to solid tumor, including breast, ovarian, and prostate. AZD1480 inhibits the STAT3 phosphorylation in vitro and in an in vivo xenograft model of human solid tumors and multiple myeloma.
