Cat No.
CEI-1064
Description
A (β-aminoethyl)ketone that acts as a potent and selective ATP-competitive inhibitor of Janus tyrosine kinase-3 (JAK3; pIC50 = 7.1). A weak inhibitor of other tyrosine kinases (pIC50 = 5.6 for EGF-R; 4.4 for JAK1). It undergoes a retro-Michael breakdown (t1/2 = 36 min at 25centigrade, pH 7.43) to another active 2-naphthylvinyl ketone analog (JAK Inhibitor V; Cat. No. 420122) [pIC50 = 6.8 for JAK3; 5.0 for EGF-R; 4.7 for JAK1].
Abbr
JAK3 Inhibitor IV(JAK3, JAK1, EGFR)
Alias
JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
Synonyms
JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK
CAS No.
58753-54-1
Targets
JAK-3, JAK-1, EGF-R
Chemical Name
2-Naphthyl-(N-isopropyl,N-benzyl)-β-aminoethylketone, HCI, ZM 39923
M.Wt
367.9
Purity
>99% by HPLC
Solubility
DMSO
Storage
-20 centigrade
