Cat No.
CEI-1097
Description
Merck 5 is a potent and reversible ATP-competitive inhibitor of the JAK kinases Jak1, Jak2, Jak3, and Tyk2. It also blocks IL2 and IL4 dependent proliferation of CTLL cells and inhibits the phosphorylation of STAT5.
Abbr
Merck 5(Jaks )
CAS No.
457081-03-7
Product_Overview
ATP-competitive inhibitor of the JAK kinases Jak1, Jak2, Jak3, and Tyk2.
Targets
Jaks
Chemical Name
6-dihydro-7H-Benz[h]imidazo[4,5-f]isoquinolin-7-one, 2-(1,1-dimethylethyl)-9-fluoro-1
M.Wt
309.34
Purity
> 95%
Solubility
DMSO > 112mg/mL Water >1mg/mL Ethanol > 4mg/mL
Storage
4 centigrade
Stability
2 years -20 centigrade Powder
1 month -4 centigrade in DMSO
More than one month -80 centigrade in DMSO
