Cat No.
CEI-0548
Description
A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC50 = 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at higher concentrations (30 μM), has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases.
Product_Overview
A potent histone demethylase JMJD3/UTX inhibitor
Targets
KDM6B
Chemical Name
3-?((6-?(4,?5-?dihydro-?1H-?benzo[d]azepin-?3(2H)-?yl)-?2-?(pyridin-?2-?yl)pyrimidin-4-yl)amino)propanoate, monosodium salt
M.Wt
610.63
Purity
>95% by HPLC
Appearance
Liquid
Formulation
DMSO ( 2 mM)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from light and moisture
Usage
For Research Use Only! Not For Use in Humans.
