Cat No.
CEI-0059
Description
SGX523 can inhibit c-Met with IC50 of 4 nM.
CAS No.
1022150-57-7
Targets
c-Met
Chemical Name
6-(6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-ylthio)quinoline
M.Wt
359.41
Purity
>99%
Solubility
DMSO 2 mg/mL Water
Storage
2 years at -20centigrade Powder
In vitro
SGX523 is a novel and selective APT- competitive inhibitor which can inhibit c-Met with IC50 of 4 nM. SGX523 is >1,000-fold selective versus the >200-fold selectivity of other protein kinases tested in biochemical assays. SGX523 inhibited MET-mediated signaling, cell proliferation, and cell migration at nanomolar concentrations but had no effect on signaling dependent on other protein kinases. And SGX523 inhibit c-Met with the dose-dependent manner.
