Cat No.
CEI-0566
Description
A vascular disrupting, antineoplastic and microtubule-depolymerizing agent. Binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. In addition, it disrupts the engagement of the endothelial cell–specific junctional molecule vascular endothelial-cadherin (VE-cadherin) and thus the activity of the VE-cadherin/β-catenikt signaling pathway, which may result in the inhibition of endothelial cell migration and capillary tube formation.
Alias
CRC 87-09, NSC 817373
Synonyms
CRC 87-09, NSC 817373
CAS No.
117048-59-6
Product_Overview
A vascular disrupting, antineoplastic and microtubule-depolymerizing agent.
Targets
Microtubule
Chemical Name
2-Methoxy-5-[(1Z)-2-(3,4,5-trimetho-xyphenyl)ethenyl]phenol
M.Wt
376.41
Purity
>99% by HPLC
Appearance
Crystalline solid
Solubility
DMSO (38 mg/ml)
Storage
-20 centigrade
Shipping Conditions
RT
Handling
Protect from light and moisture
Usage
For Research Use Only! Not For Use in Humans.
