Cat No.
CEI-1180
Description
Waglerin-1 is a 22 amino acid peptide toxin isolated from the Southeast Asian snake Trimeresurus wagleri. Two other similar peptides named Waglerin-2 and 3 are isolated from the same snake species. Waglerin-1 selectively blocks the nAChRε subunit with an IC50 of 50 nM and is a potent blocker of muscle nAChR. Waglerin-1 is also a modulator of GABA(A) receptors with potentiating and suppressing effects. Its IC50 and EC50 value is 24 μM.
Abbr
Waglerin-1
Source
Synthetic peptide
Synonyms
Waglerin-I, Wtx-1, Lethal peptide I
Product_Overview
A Potent Blocker of nAChR and a Modulator of GABA(A) Receptors
Targets
nAChR, GABA(A) receptors
M.Wt
2520 Da
Source
Synthetic peptide
Purity
>99%
Storage
Lyophilized powder can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
Reconstitution
Any other aqueous buffer. Centrifuge all product preparations before use (10000 x g 5 min).
