Cat No.
CEI-0590
Description
Potential anti-inflammatory agent. Selectively and irreversibly inhibits NF-κB activation by blocking TNF-α-induced phosphorylation of IκB-α without affecting constitutive IκB-α phosphorylation. Inhibits the TNF-α-induced surface expression of adhesion molecules ICAM-1, VCAM-1, and E-selectin in human endothelial cells with IC50 values of 5-10 μM.
CAS No.
19542-67-7
Product_Overview
A NF-κB activation inhibitor
Targets
NFKB1
Chemical Name
(E)-3-(4-Methylphenylsulfonyl)-2-propenenenitrile
M.Wt
622.84
Purity
>95% by HPLC
Appearance
Colorless film
Solubility
DMSO
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
