Cat No.
CEI-0589
Description
An immunosuppressant and a potent inhibitor of NF-κB activation in T cells, with an almost complete inhibition at 200 nM. Suppresses cytokine production (IFN-γ, TNF-α, IL-2 and IL-4) and inhibits NF-AT in peripheral blood T cells at concentrations that do not impair NF-κB and AP-1 activities. Also induces mitochondria-mediated apoptosis in leukemia cells and sensitizes CD95/CD95L-mediated apoptosis in malignant T-cells by differential regulation of CD95L and c-FLIP expression.
Alias
Rocaglamide A
Synonyms
Rocaglamide A
CAS No.
84573-16-0
Product_Overview
An immunosuppressant
Targets
NFKB1
M.Wt
228.2
Purity
>98% by HPLC
Appearance
White solid
Solubility
DMSO (100 mM) or H2O (100 mM)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and moisture
Usage
For Research Use Only! Not For Use in Humans.
