Cat No.
CEI-0716
Description
Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell.
Alias
XI-011
Synonyms
XI-011
CAS No.
59474-01-0
Product_Overview
A p53 activator
Targets
p53
Chemical Name
(10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride
M.Wt
396.83
Purity
>95%
Appearance
Yellow solid
Solubility
DMSO (>5 mg/ml)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
