Cat No.
CEI-0985
Description
A cell-permeable, water-soluble, potent inhibitor of poly(ADP-ribose) polymerase (PARP; EC50 = 20 nM). Shown to be about 10,000 times more potent than the prototypical PARP inhibitor, 3-Aminobenzamide (Cat. No. 165350; EC50 = 200 μM). Does not act as an antioxidant at higher concentrations (1 μM to 10 mM). Exhibits neuroprotection in in vivo and in vitro models of stroke.
Abbr
PJ34
Synonyms
N-(5,6-Dihydro-6-oxo-2-phenanthridi-nyl)-2-acetamide hydrochloride
CAS No.
344458-15-7
IC50
20 nM
Targets
PARP
M.Wt
331.8 Da
Purity
>98%
Appearance
White to light brown powder.
Solubility
Soluble to 100 mM in water and to 100 mM in DMSO
Stability
Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
