Cat No.
CEI-0615
Description
An inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC50 = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC?? = 1.2 μM).
Alias
Inhibitor of Wnt Production-3
Synonyms
Inhibitor of Wnt Production-3
CAS No.
687561-60-0
Product_Overview
An inhibitor of Wnt production
Targets
phosphatsae
Chemical Name
2-?[[3-?(4-?fluorophenyl)-?3,?4,?6,?7-?tetrahydro-?4-?oxothieno[3,?2-? d]pyrimidin-?2-?yl]thio]-?N-?(6-?methyl-?2-?benzothiazolyl)-?acetamide
M.Wt
211.22
Purity
>98%
Appearance
Off-white solid
Solubility
DMSO (10 mg/ml)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
