Cat No.
PHAM-263
Description
Urokinase is a serine protease (EC 3.4.21.73). Urokinase was originally isolated from human urine, but is present in several physiological locations, such as blood stream and the extracellular matrix. The primary physiological substrate is plasminogen, which is an inactive form (zymogen) of the serine protease plasmin. Activation of plasmin triggers a proteolysis cascade that, depending on the physiological environment, participates in thrombolysis or extracellular matrix degradation. This links urokinase to vascular diseases and cancer.
Abbr
uPA (Human)
Alias
uPA; Urokinase
Source
Human kidney cells
Species
Human
Form
lyophilized powder
Enzyme Commission Number
EC 3.4.21.73
CAS No.
9039-53-6
Warnings
Note: Higher activities are obtained when human plasminogen is used as substrate.
Gene Name
PLAU plasminogen activator, urokinase [ Homo sapiens ]
Synonyms
Urokinase; EC 3.4.21.73; urokinase-type plasminogen activator; uPA; U-plasminogen activator; Cellular plasminogen activator; Urinary plasminogen activator
GeneID
5328
mRNA Refseq
NM_001145031
Protein Refseq
NP_001138503
MIM
191840
UniProt ID
P00749
Chromosome Location
10q22.2
Pathway
ATF-2 transcription factor network, organism-specific biosystem; Blood Clotting Cascade, organism-specific biosystem; Complement and coagulation cascades, organism-specific biosystem.
Function
protein binding; serine-type endopeptidase activity.
