Cat No.
NATE-0228
Description
Eosinophil peroxidase is an enzyme found within the eosinophil granulocytes, innate immune cells of humans and mammals. This oxidoreductase protein is encoded by the gene EPX, expressed within these myeloid cells. EPO shares many similarities with its orthologous peroxidases, myeloperoxidase (MPO), lactoperoxidase (LPO), and thyroid peroxidase (TPO). The protein is concentrated in secretory granules within eosinophils. Eosinophil peroxidase is a heme peroxidase, its activities including the oxidation of halide ions to bacteriocidal reactive oxygen species, the cationic disruption of bacterial cell walls, and the post-translational modification of protein amino acid residues.
Abbr
EPO, Native (Human)
Alias
EPO; EPP; EPX-PEN
Source
Human Eosinophils
Species
Human
Form
Liquid
Enzyme Commission Number
EC 1.11.1.7
Bio-activity
> 1,000 U/mL (Enzymatic)
CAS No.
9003-99-0
Appearance
Clear, green to brown liquid
Molecular Mass
77 kda (~53 kDa mw heavy chain, ~13 kDa mw light chain)
Purification
> 98% (SDS-PAGE)
Specificity
> 1 kDa U/mg protein
Unit Definition
One unit of eosinophil peroxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of ? micromole of tetraguaiacol per minute at pH 7.0 and 25°C.
Gene Name
EPX eosinophil peroxidase [Homo sapiens]
Synonyms
EPX; eosinophil peroxidase; EPO; EPP; EPX PEN; EPX-PEN; EC 1.11.1.7; 9003-99-0; peroxidase; lactoperoxidase; guaiacol peroxidase; plant peroxidase; Japanese radish peroxidase; horseradish peroxidase (HRP); soybean peroxidase (SBP); extensin peroxidase; heme peroxidase; oxyperoxidase; protoheme peroxidase; pyrocatechol peroxidase; scopoletin peroxidase; Coprinus cinereus peroxidase; Arthromyces ramosus peroxidase
GeneID
8288
mRNA Refseq
NM_000502
Protein Refseq
NP_000493
MIM
131399
UniProt ID
P11678
Chromosome Location
17q23.1
Pathway
Asthma, organism-specific biosystem; Asthma, conserved biosystem
Function
heme binding; metal ion binding; oxidoreductase activity; peroxidase activity
