Cat No.
NATE-0460
Description
Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus.
Abbr
MPOB, Native (Human)
Alias
MPOB; EC 1.11.1.7; 9003-99-0
Source
Human Neutrophils
Species
Human
Form
Liquid
Enzyme Commission Number
EC 1.11.1.7
Bio-activity
> 500 U/mL
CAS No.
9003-99-0
Molecular Mass
149 kDa
Purification
> 96% (SDS-PAGE)
Unit Definition
One unit of Myeloperoxidase will catalyze the consumption of one micromole of hydrogen peroxide and the production of 1/4 micromole of tetraguaiacol per minute at pH 7.0 and 25°C.
Gene Name
MPO myeloperoxidase [Homo sapiens]
Synonyms
MPOB; MPO B; Myeloperoxidase Isoform B; EC 1.11.1.7; 9003-99-0
GeneID
4353
mRNA Refseq
NM_000250
Protein Refseq
NP_000241
MIM
606989
UniProt ID
P05164
Chromosome Location
17q21.3-q23
Pathway
C-MYB transcription factor network, organism-specific biosystem; Folate Metabolism, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Selenium Pathway, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem
Function
chromatin binding; heme binding; heparin binding; metal ion binding; oxidoreductase activity; peroxidase activity
