Cat No.
NATE-0457
Description
Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. MPO has a heme pigment, which causes its green color in secretions rich in neutrophils, such as pus and some forms of mucus.
Abbr
MPO, Native (Human)
Alias
MPO; myelo
Source
Human leuk ocytes
Species
Human
Form
Lyophilized from 50 mM sodium acetate buffer, pH 6.0, 0.1 M sodium chloride
Enzyme Commission Number
EC 1.11.1.7
Bio-activity
> 50 units/mg protein
CAS No.
9003-99-0
Unit Definition
One unit will produce an increase in absorbance (A470) of 1.0 per min at pH 7.0 and 25°C, calculated from the initial rate of reaction using guaiacol as substrate. Total reaction volume: 3.035 mL.
Warnings
Lysosomal heme-containing protein. Source material tested and found negative for antibody to HIV and for HBSAG.
Gene Name
MPO myeloperoxidase [Homo sapiens]
Synonyms
MPO; myeloperoxidase; Peroxidase; myelo; EC 1.11.1.7; 9003-99-0
GeneID
4353
mRNA Refseq
NM_000250
Protein Refseq
NP_000241
MIM
606989
UniProt ID
P05164
Chromosome Location
17q21.3-q23
Pathway
C-MYB transcription factor network, organism-specific biosystem; Folate Metabolism, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem; Phagosome, organism-specific biosystem; Phagosome, conserved biosystem; Selenium Pathway, organism-specific biosystem; Transcriptional misregulation in cancer, organism-specific biosystem
Function
chromatin binding; heme binding; heparin binding; metal ion binding; oxidoreductase activity; peroxidase activity
