Cat No.
NATE-0919
Description
Thyroid Peroxidase (TPO) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. Its identity with the formerly so-called "microsomal antigen" has been shown several years ago. As an integral membrane glycoprotein it is restricted to the apical plasma membrane of the follicular epithelial cells and comprises two identical subunits of approx. 100 kDa molecular weight. The hemoprotein TPO plays a key role in the thyroid hormone biosynthesis by catalysing both the iodination of tyrosyl residues and the coupling of iodotyrosyl residues in thyroglobulin (TG) to form precursors of the thyroid hormones T4 and T3.
Abbr
TPO, Recombinant (Human)
Alias
TPO; MSA; TPX
Source
Sf9 insect cells
Species
Human
Concentration
0.15-0.375 μg/ml (depending on the type of ELISA plate and coating buffer). Suitable for biotinylation and iodination.
Molecular Mass
92,872 Da
Purification
Greater than 95% as determined by SDS-PAGE.
Applications
Western-Blot
Synonyms
Thyroid peroxidase; EC 1.11.1.8; TPO; MSA; TPX; iodotyrosine deiodase; iodinase; iodoperoxidase (heme type); iodide peroxidase-tyrosine iodinase; iodotyrosine deiodinase; monoiodotyrosine deiodinase; thyroperoxidase; tyrosine iodinase; iodide peroxidase
