Cat No.
NATE-1479
Description
Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene. The protein encoded by this gene catalyzes the transfer of galactose to lactosylceramide to form globotriaosylceramide, which has been identified as the P(k) antigen of the P blood group system. The encoded protein, which is a type II membrane protein found in the Golgi, is also required for the synthesis of the bacterial verotoxins receptor.
Abbr
LgtC, Recombinant (Neisseria meningitides)
Source
E. coli
Species
Neisseria meningitides
Enzyme Commission Number
EC 2.4.1.228
Molecular Mass
34 kDa
Purification
min 95% by SDS-PAGE
Unit Definition
One unit is defined as the amount of enzyme that catalyzes the formation of 1 μmol of Galα1,4Lac from UDP-Gal and Lactose per minute at 37 °C.
Synonyms
lactosylceramide 4-alpha-galactosyltransferase; Galbeta1-4Glcbeta1-Cer alpha1,4-galactosyltransferase; globotriaosylceramide/CD77 synthase; histo-blood group Pk UDP-galactose; UDP-galactose:lactosylceramide 4II-alpha-D-galactosyltransferase; UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl(1<->1)ceramide 4II-alpha-D-galactosyltransferase; UDP-galactose:beta-D-galactosyl-(1->4)-D-glucosyl-(1<->1)-ceramide 4II-alpha-D-galactosyltransferase
