Cat No.
NATE-0067
Description
Alanine transaminase (ALT) is a transaminase enzyme (EC 2.6.1.2). It is also called alanine aminotransferase (ALAT) and was formerly called serum glutamate-pyruvate transaminase (SGPT) or serum glutamic-pyruvic transaminase (SGPT). ALT is found in plasma and in various body tissues, but is most common in the liver. It catalyzes the two parts of the alanine cycle. Serum ALT level, serum AST (aspartate transaminase) level, and their ratio (AST/ALT ratio) are commonly measured clinically as biomarkers for liver health. The tests are part of blood panels.
Abbr
ALT, Native (Human)
Alias
ALT; ALAT; GPT
Source
Human Heart
Species
Human
Form
Liquid
Enzyme Commission Number
EC 2.6.1.2
Bio-activity
> 250 U/mL (Dimension Clinical Chemistry System)
CAS No.
9000-86-6
Purification
Purified
Specificity
> 10 U/mg protein
Unit Definition
One unit will catalyze the transamination of one micromole of L-alanine to alpha-ketoglutarate, forming L-glutamate and pyruvate, per minute at 37°C and pH 7.4.
Gene Name
GPT glutamic-pyruvate transaminase (alanine aminotransferase) [Homo sapiens]
Synonyms
Alanine transaminase; ALT; EC 2.6.1.2; alanine aminotransferase; ALAT; glutamic-pyruvic transaminase; glutamic-alanine transaminase; GPT; β-alanine aminotransferase; alanine-α-ketoglutarate aminotransferase; alanine-pyruvate aminotransferase; glutamic acid-pyruvic acid transaminase; glutamic-pyruvic aminotransferase; L-alanine aminotransferase; L-alanine transaminase; L-alanine-α-ketoglutarate aminotransferase; pyruvate transaminase; pyruvate-alanine aminotransferase; pyruvate-glutamate transaminase
GeneID
2875
mRNA Refseq
NM_005309
Protein Refseq
NP_005300
MIM
138200
UniProt ID
P24298
Chromosome Location
8q24.2-qter
Pathway
Alanine and aspartate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, organism-specific biosystem; Alanine, aspartate and glutamate metabolism, conserved biosystem; Amino acid synthesis and interconversion (transamination), organism-specific biosystem; Metabolic pathways, organism-specific biosystem; Metabolism, organism-specific biosystem; Metabolism of amino acids and derivatives, organism-specific biosystem
Function
1-aminocyclopropane-1-carboxylate synthase activity; L-alanine:2-oxoglutarate aminotransferase activity; L-alanine:2-oxoglutarate aminotransferase activity; pyridoxal phosphate binding; transaminase activity
