Cat No.
NATE-0282
Description
Glucokinase (EC 2.7.1.2) is an enzyme that facilitates phosphorylation of glucose to glucose-6-phosphate. Glucokinase occurs in cells in the liver, pancreas, gut, and brain of humans and most other vertebrates. In each of these organs it plays an important role in the regulation of carbohydrate metabolism by acting as a glucose sensor, triggering shifts in metabolism or cell function in response to rising or falling levels of glucose, such as occur after a meal or when fasting. Mutations of the gene for this enzyme can cause unusual forms of diabetes or hypoglycemia.
Abbr
GCK, Native (Bacillus stearothermophilus)
Alias
GCK; FGQTL3; GK; GLK
Species
Bacillus stearothermophilus
Form
Lyophilized powder containing Tris buffer salts
Enzyme Commission Number
EC 2.7.1.2
Bio-activity
> 300 units/mg protein
CAS No.
9001-36-9
Unit Definition
One unit will phosphorylate 1.0 μmole of D-glucose to D-glucose 6-phosphate per min at pH 9.0 at 30°C.
Synonyms
EC 2.7.1.2; glucokinase; glucokinase (phosphorylating); 9001-36-9; GCK; FGQTL3; GK; GLK; HHF3; HK4; HKIV; HXKP; LGLK; MODY2
