Cat No.
NATE-0309
Description
In enzymology, a guanylate kinase (EC 2.7.4.8) is an enzyme that catalyzes the chemical reaction:ATP + GMP? ADP + GDP. Thus, the two substrates of this enzyme are ATP and GMP, whereas its two products are ADP and GDP. This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a phosphate group as acceptor. This enzyme participates in purine metabolism.
Abbr
GMP kinase, Native (Bovine)
Alias
GMP kinase
Source
Bovine brain
Species
Bovine
Form
Lyophilized powder containing potassium phosphate buffer salts
Enzyme Commission Number
EC 2.7.4.8
Bio-activity
10-40 units/mg protein
CAS No.
9026-59-9
Unit Definition
One unit will convert 1.0 μmole each of GMP and ATP to GDP and ADP per min at pH 7.5 at 30°C.
Gene Name
GUK1 guanylate kinase 1 [Bos taurus]
Synonyms
guanylate kinase; deoxyguanylate kinase; 5'-GMP kinase; GMP kinase; guanosine monophosphate kinase; ATP:GMP phosphotransferase; EC 2.7.4.8; 9026-59-9
GeneID
281217
mRNA Refseq
NM_001159412
Protein Refseq
NP_001152884
UniProt ID
P46195
Chromosome Location
chromosome: 7
Pathway
Abacavir metabolism, organism-specific biosystem; Guanine ribonucleotide biosynthesis IMP => GDP,GTP, organism-specific biosystem; Metabolism of nucleotides, organism-specific biosystem
Function
ATP binding; guanylate kinase activity
