Cat No.
NATE-0335
Description
Hck is a member of the Src family of non-receptor associated protein tyrosine kinases (PTK). Hck has been shown to associate with and be activated by Bcr-Abl, which is a protein-tyrosine kinase that is expressed in chronic myelogenous leukemia.
Abbr
Hck, Recombinant (Human)
Alias
HCK; JTK9; p59Hck; p61Hck;
Source
E. coli BL21
Species
Human
Form
Supplied as a solution in 50 mM Tris HCl, pH 7.4, 1 mM EDTA and 1 mM DTT
Bio-activity
> 200 units
Unit Definition
One unit will phosphorylate 1.0 picomole of Tyr15 of the peptide substrate pcdc2 6-20 per minute at 30°C at pH 7.4.
Package
vial of > 200 units
Applications
Hck is a protein-tyrosine kinase that is expressed in hemopoietic cells. It is used in leukemia research
Gene Name
HCK hemopoietic cell kinase [Homo sapiens]
Synonyms
Hck; HCK; tyrosine-protein kinase HCK; JTK9; p59Hck; p61Hck
GeneID
3055
mRNA Refseq
NM_001172129
Protein Refseq
NP_001165600
MIM
142370
UniProt ID
P08631
Chromosome Location
20q11-q12
Pathway
Alpha-synuclein signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem; Chemokine signaling pathway, conserved biosystem; Class I PI3K signaling events, organism-specific biosystem; Cytokine Signaling in Immune system, organism-specific biosystem
Function
ATP binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity
