Cat No.
NATE-1000
Description
Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Mutations in the PNP gene are responsible for purine nucleoside phosphorylase deficiency.
Abbr
PUNP, Recombinant (E. coli)
Alias
PNPase; PUNP
Source
E. coli
Species
E. coli
Enzyme Commission Number
EC 2.4.2.1
Bio-activity
27 U/mg
Appearance
Colourless clear liquid
Molecular Mass
156 kDa
Purification
> 95 %
Applications
These enzymes are widely used for the synthesis of modified nucleotides (virasol, cladribine, fludarabine) which are efficient antiviral and antitumor drugs.
Synonyms
purine-nucleoside phosphorylase; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; EC 2.4.2.1; 9030-21-1
