Cat No.
NATE-0644
Description
Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes adenosine into adenine, inosine into hypoxanthine, and guanosine into guanine. Mutations in the PNP gene are responsible for purine nucleoside phosphorylase deficiency.
Abbr
PUNP, Recombinant
Alias
PNPase; PUNPI; PUNPII
Source
E. coli
Form
buffered aqueous solution (100 mM phosphate buffer with 1 mM MgCl2
Enzyme Commission Number
EC 2.4.2.1
Bio-activity
> 120 U/mL
CAS No.
9030-21-1
Unit Definition
1 U will cause the phosphorolysis of 1 μmol of inosine to hypoxanthine and ribose 1-phosphate per minute at pH 7.4 at 25°C.
Applications
Purine nucleoside phosphorylase is used to study nucleotide salvage pathways and purine metabolism. It is used to study purine nucleoside phosphorylase deficiency and responsible PNP genetic mutations. This product is recombinant and expressed in E. coli.
Synonyms
purine-nucleoside phosphorylase; inosine phosphorylase; PNPase; PUNPI; PUNPII; inosine-guanosine phosphorylase; nucleotide phosphatase; purine deoxynucleoside phosphorylase; purine deoxyribonucleoside phosphorylase; purine nucleoside phosphorylase; purine ribonucleoside phosphorylase; EC 2.4.2.1; 9030-21-1
