Cat No.
NATE-0019
Description
Acetylcholinesterase, also known as AChE or acetylhydrolase, is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs to carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Abbr
AChE, Native (Human erythrocytes)
Alias
AChE; AcCholE; Acetyl
Source
Human erythrocytes
Species
Human
Form
buffered aqueous solution. Solution in 20 mM HEPES, pH 8.0, containing 0.1% TRITON X-100
Enzyme Commission Number
EC 3.1.1.7
Bio-activity
> 500 units/mg protein (BCA)
CAS No.
9000-81-1
Molecular Mass
~80 kDa
Unit Definition
One unit will hydrolyze 1.0 μmole of acetylthiocholine iodide per min at pH 7.4 at 37°C.
Applications
Acetylcholinesterase (AChE) from Creative Enzymes has been used in the structure-activity study of phosphoramido acid esters as inhibitors of AChE.
Gene Name
ACHE acetylcholinesterase [Homo sapiens]
Synonyms
true cholinesterase; choline esterase I; cholinesterase; acetylthiocholinesterase; acetylcholine hydrolase; acetyl; β-methylcholinesterase; AcCholE; EC 3.1.1.7; 9000-81-1; Acetylcholinesterase; AChE; acetylhydrolase
GeneID
43
mRNA Refseq
NM_000665
Protein Refseq
NP_000656
MIM
100740
UniProt ID
P22303
Chromosome Location
7q22
Pathway
ATF-2 transcription factor network, organism-specific biosystem; Acetylcholine Synthesis, organism-specific biosystem; Biogenic Amine Synthesis, organism-specific biosystem; Cholinergic synapse, organism-specific biosystem; Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem; Monoamine Transport, organism-specific biosystem
Function
acetylcholine binding; acetylcholine binding; acetylcholinesterase activity; acetylcholinesterase activity; beta-amyloid binding; carboxylesterase activity; cholinesterase activity; collagen binding; hydrolase activity; laminin binding; protein binding; protein homodimerization activity; protein homodimerization activity; protein self-association; serine hydrolase activity
