Cat No.
NATE-0018
Description
Acetylcholinesterase, also known as AChE or acetylhydrolase, is a hydrolase that hydrolyzes the neurotransmitter acetylcholine. AChE is found at mainly neuromuscular junctions and cholinergic brain synapses, where its activity serves to terminate synaptic transmission. It belongs to carboxylesterase family of enzymes. It is the primary target of inhibition by organophosphorus compounds such as nerve agents and pesticides.
Abbr
AChE, Native (Electrophorus electricus (electric eel))
Alias
AChE; AcCholE; Acetyl
Species
Electrophorus electricus (electric eel)
Form
lyophilized powder
Enzyme Commission Number
EC 3.1.1.7
Bio-activity
> 1 ,000 units/mg protein; 200-1 ,000 units/mg protein
CAS No.
9000-81-1
Molecular Mass
280 kDa
Isoelectric point
~5.3
Unit Definition
One unit will hydrolyze 1.0 μmole of acetylcholine to choline and acetate per min at pH 8.0 at 37°C.
Applications
The enzyme has been used as a reference to to evaluate the effect of aspartame metabolites on hippocampal acetylcholinesterase activity. The enzyme has also been used in immobilization studies for the rapid detection of acetylthiocholine chloride.
Synonyms
true cholinesterase; choline esterase I; cholinesterase; acetylthiocholinesterase; acetylcholine hydrolase; acetyl; β-methylcholinesterase; AcCholE; EC 3.1.1.7; 9000-81-1; Acetylcholinesterase; AChE; acetylhydrolase
