Cat No.
NATE-0032
Description
Adenosine deaminase is an enzyme (EC 3.5.4.4) involved in purine metabolism. It is needed for the breakdown of adenosine from food and for the turnover of nucleic acids in tissues. Present in virtually all mammalian cells, its primary function in Humans is the development and maintenance of the immune system.
Abbr
ADA, Recombinant (Bovine)
Alias
ADA; adenosine deaminase
Source
E. coli
Species
Bovine
Form
ammonium sulfate suspension. Suspension in 3.2 M (NH4)2SO4, 0.01 M potassium phosphate, pH 6.0
Enzyme Commission Number
EC 3.5.4.4
Bio-activity
60-130 units/mg protein; > 130 units/mg protein; 150-200 units/mg protein
CAS No.
9026-93-1
Molecular Mass
32.5-33 kDa
Isoelectric point
4.85
Unit Definition
One unit will deaminate 1.0 μmole of adenosine to inosine per min at pH 7.5 at 25°C.
Applications
Adenosine deaminase is useful in various molecular biology assays, such as glycerol release assays. Adenosine deaminase is a potential target for treatments of combined immunodeficiency disease.
Gene Name
ADA adenosine deaminase [Bos taurus]
Synonyms
ADA; adenosine deaminase; adenosine aminohydrolase; 9026-93-1; EC 3.5.4.4
GeneID
280712
mRNA Refseq
NM_173887
Protein Refseq
NP_776312
UniProt ID
P56658
Chromosome Location
chromosome: 13
Pathway
Metabolic pathways, organism-specific biosystem; Primary immunodeficiency, organism-specific biosystem; Purine metabolism, conserved biosystem
Function
adenosine deaminase activity; protein binding; zinc ion binding
