Cat No.
NATE-0167
Description
Cathepsin B has been found to cleave procaspase 1 and procaspase 11 and to induce apoptosis in digitonin-permeabilized cells. Translocation of cathepsin B from the cytoplasm to the nucleus contributes to bile salt induced apoptosis of Rat hepatocytes. Levels of cathepsin B in PC12 cells significantly decrease 12 to 24 hours after apoptosis is induced.
Abbr
CTSB, Native (Bovine)
Alias
CTSB; cathepsin B; APPS; CPSB
Source
Bovine spleen
Species
Bovine
Form
Lyophilized powder containing sodium phosphate, sodium chloride and ~6% EDTA as stabilizer.
Bio-activity
> 10 units/mg protein
CAS No.
9047-22-7
Composition
Protein, > 30% biuret
Unit Definition
One unit will hydrolyze 1 μmole of Z-lysine p-nitrophenyl ester per min at pH 5.0 at 25°C.
Gene Name
CTSB cathepsin B [Bos taurus]
Synonyms
CTSB; cathepsin B; 9047-22-7; APPS; CPSB; cathepsin B1 (obsolete); cathepsin II
GeneID
281105
mRNA Refseq
NM_174031
Protein Refseq
NP_776456
UniProt ID
P07688
Chromosome Location
chromosome: 8
Pathway
Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Assembly of collagen fibrils and other multimeric structures, organism-specific biosystem
Function
collagen binding; cysteine-type endopeptidase activity; proteoglycan binding
