Cat No.
NATE-0144
Description
Colipase is a protein co-enzyme required for optimal enzyme activity of pancreatic lipase. It is secreted by the pancreas in an inactive form, procolipase, which is activated in the intestinal lumen by trypsin. Its function is to prevent the inhibitory effect of bile salts on the lipase-catalyzed intraduodenal hydrolysis of dietary long-chain triglycerides. In humans, the colipase protein is encoded by the CLPS gene.
Abbr
CLPS, Native (Porcine)
Alias
CLPS; colipase
Source
Porcine pancreas
Species
Porcine
Form
Liquid
Bio-activity
10 KU-20 KU/mL
Concentration
0.15-0.52 mg/mL
Appearance
Colourless liquid
Unit Definition
One unit of activity is defined as the amount of enzyme that will catalyze the release of 1.0 micromole of fatty acid from tributyrin per minute at 20°C under the standard assay method conditions.
Applications
Pancreatic colipase is a required co-factor for pancreatic lipase, being necessary for its activity during hydrolysis of dietary triglycerides in the presence of bile salts
Gene Name
CLPS colipase, pancreatic [Sus scrofa]
Synonyms
CLPS; colipase; pancreatic colipase
GeneID
397407
mRNA Refseq
NM_214203
Protein Refseq
NP_999368
UniProt ID
P02703
Chromosome Location
7; 7
Pathway
Digestion of dietary lipid, organism-specific biosystem; Fat digestion and absorption, organism-specific biosystem; Lipid digestion, mobilization, and transport, organism-specific biosystem
Function
enzyme activator activity
