Cat No.
NATE-0172
Description
Cathepsin D is an endosomal-lysosomal aspartic protease implicated in breast cancer metastasis and Alzheimer’s disease. Lysosomal release of cathepsin D has been found to precede cytochrome c release and loss of membrane potential in apoptotic human foreskin fibroblasts. Cathepsin D levels in PC12 cells increase 12 to 24 hours after apoptosis is induced.
Abbr
CTSD, Native (Human)
Alias
CTSD; CPSD
Source
Human liver
Species
Human
Form
lyophilized powder
Enzyme Commission Number
EC 3.4.23.5
Bio-activity
> 250 units/mg protein (E1%/280)
CAS No.
9025-26-7
Unit Definition
One unit will produce an increase in A280 of 1.0 in 30 min at pH 3.3 at 37°C measured as TCA-soluble products using acid-denatured hemoglobin as substrate (1 cm light path).
Gene Name
CTSD cathepsin D [Homo sapiens]
Synonyms
CTSD; cathepsin D; CLN10; CPSD; HEL-S-130P; EC 3.4.23.5; 9025-26-7
GeneID
1509
mRNA Refseq
NM_001909
Protein Refseq
NP_001900
MIM
116840
UniProt ID
P07339
Chromosome Location
11p15.5
Pathway
Ceramide signaling pathway, organism-specific biosystem; Direct p53 effectors, organism-specific biosystem; LKB1 signaling events, organism-specific biosystem; Lysosome, organism-specific biosystem; Lysosome, conserved biosystem; Tuberculosis, organism-specific biosystem; Tuberculosis, conserved biosystem
Function
aspartic-type endopeptidase activity; peptidase activity
