Cat No.
NATE-0176
Description
Cathepsin H is a protein that in humans is encoded by the CTSH gene. The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.
Abbr
CTSH, Native (Human)
Alias
CTSH; ACC4; ACC5
Source
Human Liver
Species
Human
Form
Liquid
Molecular Mass
28 kDa
Purification
> 95% (SDS-PAGE)
Optimum pH
4.5
Gene Name
CTSH cathepsin H [Homo sapiens]
Synonyms
CTSH; cathepsin H; CPSB; ACC-4; ACC-5; ACC4; ACC5; CPSB; minichain
GeneID
1512
mRNA Refseq
NM_004390
Protein Refseq
NP_004381
MIM
116820
UniProt ID
P09668
Chromosome Location
15q25.1
Pathway
Lysosome, organism-specific biosystem; Lysosome, conserved biosystem
Function
HLA-A specific activating MHC class I receptor activity; aminopeptidase activity; apoptotic protease activator activity; cysteine-type endopeptidase activity; cysteine-type peptidase activity; endopeptidase activity; kininogen binding; peptidase activity; protein binding; serine-type endopeptidase activity; thyroid hormone binding
