Cat No.
NATE-0177
Description
Cathepsin L (EC 3.4.22.15, Aldrichina grahami cysteine proteinase) is an important lysosomal endopeptidase enzyme which is involved in the initiation of protein degradation. It is a member of the Peptidase C1 family, which play an important role in diverse processes including normal lysosome mediated protein turnover, antigen and proprotein processing, and apoptosis. Cathepsin L has been reported in many organisms including fish, birds and mammals.
Abbr
CTSL, Native (Human)
Alias
CTSL
Source
Human liver
Species
Human
Form
Solution in in 20 mM malonate, pH 5.5, 1 mM EDTA, and 400 mM NaCl.
Enzyme Commission Number
EC 3.4.22.15
Bio-activity
> 0.5 units/mg protein
CAS No.
60616-82-2
Unit Definition
One unit will hydrolyze 1.0 μmole of Z-Phe-Arg-AFC per minute at pH 5.5 at 25°C.
Applications
The most powerful of the lysosomal proteinases. It has a higher specific activity than cathepsin B and H in the degradation of a variety of physiological protein substrates.
Gene Name
CTSL cathepsin L [Homo sapiens]
Synonyms
cathepsin L; CTSL; EC 3.4.22.15; Aldrichina grahami cysteine proteinase; 60616-82-2
GeneID
1514
mRNA Refseq
NM_001257971
Protein Refseq
NP_001244900
MIM
116880
UniProt ID
P07711
Chromosome Location
9q21.33
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Endosomal/Vacuolar pathway, organism-specific biosystem
Function
collagen binding; cysteine-type peptidase activity; histone binding
