Cat No.
NATE-0178
Description
Cathepsin S is a lysosomal cysteine protease found primarily in the spleen and in lung macrophages. Its level is elevated in the brain tissue of those with Alzheimer's disease and Down syndrome. Cathepsin S may function in the processing of amyloid precursor protein to amyloid beta peptides.
Abbr
CTSS, Native (Human)
Alias
CTSS
Source
Human spleen
Species
Human
Form
lyophilized powder. Lyophilized from 100 mM sodium acetate, pH 5.5, and 1 mM EDTA.
Enzyme Commission Number
EC 3.4.22.27
Unit Definition
One unit will hydrolyze Z-Val-Val-Arg-NHMec to yield 2 nanomoles of 7-amino-4-mehtylcoumarin in 10 minutes at pH 6.5 at 25°C
Applications
Cathepsin S from human spleen has been used in a study to assess the sequence identification, tissue distribution and polymorphism of the porcine cathepsin D (CTSD) Gene. Cathepsin S from human spleen has also been used in a study to investigate a new promising camptothecin analogue-polysaccharide conjugate.
Gene Name
CTSS cathepsin S [Homo sapiens]
Synonyms
CTSS; cathepsin S; EC 3.4.22.27; FLJ50259; MGC3886
GeneID
1520
mRNA Refseq
NM_001199739
Protein Refseq
NP_001186668
MIM
116845
UniProt ID
P25774
Chromosome Location
1q21
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing and presentation, organism-specific biosystem; Endosomal/Vacuolar pathway, organism-specific biosystem
Function
cysteine-type endopeptidase activity; peptidase activity
