Cat No.
NATE-0269
Description
Glucose 6-phosphatase (EC 3.1.3.9, G6Pase) is an enzyme that hydrolyzes glucose-6-phosphate, resulting in the creation of a phosphate group and free glucose. Glucose is then exported from the cell via glucose transporter membrane proteins. This catalysis completes the final step in gluconeogenesis and glycogenolysis and therefore plays a key role in the homeostatic regulation of blood glucose levels.
Abbr
G6Pase, Native (Rabbit)
Alias
G6Pase
Source
Rabbit liver
Species
Rabbit
Form
powder with sucrose
Enzyme Commission Number
EC 3.1.3.9
Bio-activity
> 0.05 units/mg protein
CAS No.
9001-39-2
Purification
Protein ~30 % (balance mostly sucrose)
Unit Definition
One unit will release 1.0 μmole of inorganic phosphate from glucose 6-phosphate per min at pH 6.5 at 37°C.
Applications
Glucose-6-Phosphatase was used to study the effects of Clausena anisata (Wild hook leaf) extracts on selected diabetes-related metabolizing enzymes.
Warnings
It has been reported that glucose-6-phosphatase, inorganic pyrophosphatase, and pyrophosphate glucose phosphotransferase are asseciated with a single protein that catalyzes three different reactions: a) glucose 6-phosphate + H2O → glucose + Pi b) PPi + H2O → 2 Pi c) glucose + PPi or nucleoside-DP or-TP → glucose 6-phosphate + Pi or nucleoside-MP.
Synonyms
EC 3.1.3.9; glucose 6-phosphate phosphatase; G6Pase; 9001-39-2; glucose-6-phosphatase
