Cat No.
CEI-0403
Description
Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin family Endostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant human Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
Alias
Human Endostatin, h-Endostatin, rh-Endostatin, recombinant human Endostatin
Synonyms
Human Endostatin, h-Endostatin, rh-Endostatin, recombinant human Endostatin
Product_Overview
An anti-angiogenic agent
Targets
Angiogenesis
M.Wt
461.6
Purity
>95% by HPLC
Appearance
White solid
Solubility
DMSO
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and moisture
Usage
For Research Use Only! Not For Use in Humans.
