Cat No.
CEI-0401
Description
A macrolide antibiotic isolated from Streptomyces sp. An antiangiogenic (IC50 = 0.8 nM) agent. Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Also acts as a CDK inhibitor.
Alias
Treponemycin; U 78548; C2989
Synonyms
Treponemycin; U 78548; C2989
CAS No.
7184-60-3
Product_Overview
An angiogenesis inhibitor
Targets
Angiogenesis
M.Wt
274.18
Purity
>99%
Appearance
White to off-white solid
Solubility
DMSO (~ 5 mg/ml)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
