Cat No.
CEI-0400
Description
A small molecule anaphase-promoting complex/cyclosome (APC/C) inhibitor that stabilizes APC/C substrates in mitotic Xenopus extracts. TAME binds to APC and prevents its activation by Cdc20 and Cdh1. In the absence of APC substrates, TAME ejects Cdc20 from the APC by promoting Cdc20 autoubiquitination in its N-terminal region. TAME also stabilizes cyclin B1 by prematurely terminating ubiquitination.
Alias
N-p-Tosyl-L-arginine methyl ester hydrochloride
Synonyms
N-p-Tosyl-L-arginine methyl ester hydrochloride
CAS No.
1784-03-8
Product_Overview
An anaphase-promoting complex/cyclosome (APC/C) inhibitor
Targets
anaphase-promoting complex/cyclosome (APC/C)
M.Wt
367.2
Purity
>90% by ?1V-NMR
Appearance
Yellow solid
Solubility
DMSO or H?O
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
