Cat No.
CEI-0410
Description
A BET bromodomain inhibitor that interacts with BRD4 and BRD3 BET proteins and displaces them from chromatin; displays high efficacy against human and murine MLL-fusion leukemic cell lines, through the induction of early cell cycle arrest and apoptosis. The mode of action is, at least in part, due to suppressing the transcription of key genes (BCL2, C-MYC and CDK6) that are critical for MLL-fusion leukemia maintenance.
Alias
GSK1210151A
Synonyms
GSK1210151A
CAS No.
1300031-49-5
Product_Overview
A BET bromodomain inhibitor
Targets
BRD4, BRD3
M.Wt
434.27
Purity
>95% by HPLC
Appearance
Yellow solid
Solubility
DMSO
Storage
+4 centigrade
Shipping Conditions
RT
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
