Cat No.
CEI-0452
Description
A specific inhibitor of Wnt/β-catenin signaling pathway. It down-regulates beta-catenin/T cell factor signaling by specifically binding to cyclic AMP response element-binding protein (CBP). ICG-001 selectively induces apoptosis in transformed cells but not in normal colon cells, reduces in vitro growth of colon carcinoma cells, and is efficacious in the Min mouse and nude mouse xenograft models of colon cancer.
CAS No.
847591-62-2
Product_Overview
A specific inhibitor of Wnt/β-catenin signaling pathway
Targets
CREB1
Chemical Name
(6S,9aS)-Hexahydro-6-[(4-hydroxyphe-nyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(-phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-c-arboxamide
M.Wt
516.67
Purity
>95% by HPLC
Appearance
Off-white solid
Solubility
DMSO (>10 mg/ml)
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from air and moisture
Usage
For Research Use Only! Not For Use in Humans.
