Cat No.
CEI-0379
Description
Levofloxacin
Alias
Levaquin, Tavanic
Synonyms
Levaquin, Tavanic
CAS No.
100986-85-4
Targets
DNA gyrase
M.Wt
361.37
Purity
>99%
Solubility
DMSO 24 mg/mL, Water 11 mg/mL, Ethanol 21 mg/mL
Storage
2 years at -20centigrade Powder
In vitro
Levofloxacin(Levaquin) is a synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited. [1]
