Cat No.
CEI-0562
Description
A semi-synthetic vinca alkaloid that displays potent anti-mitotic and anti-tumor properties. Its main mechanism of action is thought to be inhibition of microtubule dynamics, which results in mitotic arrest and eventual cell death. Acts as a microtubule destabilizing agent. At high concentrations, it stimulates microtubule depolymerization and mitotic spindle destruction. At lower clinically relevant concentrations, vinorelbine blocks mitotic progression. Its main targets are tubulin and microtubules. Unlike the taxanes, which bind poorly to soluble tubulin, vinorelbine can bind both soluble and microtubule-associated tubulin.
CAS No.
125317-39-7
Product_Overview
An anti-mitotic and antitumor agent
Targets
DNMTs
Chemical Name
3′,4′-Didehydro-4′-deoxy-C′-norvincaleukoblastine [R-(R*,R*)-2-3-dihydroxybutanedioate (1:2)salt], 5′-Noranhydrovinoblastine tartrate, KW-2307, NVB, Navelbine tartrate
M.Wt
326.35
Purity
>98% by HPLC
Appearance
White to off-white solid
Solubility
DMSO (100 mM)
Storage
-20 centigrade
Shipping Conditions
Gel Pack
Handling
Protect from air and light
Usage
For Research Use Only! Not For Use in Humans.
