Cat No.
CEI-0026
Description
WZ3146
CAS No.
1214265-56-1
Targets
EGFR(L858R)
M.Wt
464.95
Purity
>99%
Solubility
No
Storage
2 years at -20 centigrade
In vitro
As an irreversible inhibitor, WZ3146 can inhibit EGFR(L858R) and EGFR(E746_A750) with IC50 of 2 nM and 2 nM, respectively. WZ3146 is profiled against Ba/F3 cells transformed with TEL fusions of BMX, BLK, JAK2 and JAK3. WZ4002, which possesses an ortho-methoxy group at the C2-aniline substituent, is more selective for EGFR than WZ3146.
