Cat No.
CEI-0486
Description
Cell-permeable. UNC0638 is a potent G9a HMTase inhibitor, exhibiting an IC50 value of <15 nM in vitro. UNC0638 also inhibits GLP, a closely-related H3K9 HMTase, with an IC50 value of 19 nM, but is more than 10,000-fold selective against SET7/9 (a H3K4 HMTase), SET8 (a H4K20 HMTase), PRMT3, and SUV39H2. UNC0638 inhibits H3K9 dimethylation in MDA-MB231 cells with an IC50 value of 81 nM and demonstrates favorable separation of functional and toxic effect.
CAS No.
1255580-76-7
Product_Overview
Apotent G9a HMTase inhibitor
Targets
EHMT2
Chemical Name
2-?Cyclohexyl-?6-?methoxy-?N-?[1-?(1-?methylethyl)-?4-?piperidinyl]-?7-?[3-?(1-?pyrrolidinyl)propoxy]-?4-?quinazolinamine
M.Wt
307.39
Purity
>98% by HPLC
Appearance
White solid
Solubility
DMSO ( 1mg/ml)
Storage
-20 centigrade
Shipping Conditions
RT
Handling
Protect from air, light and moisture
Usage
For Research Use Only! Not For Use in Humans.
