Cat No.
CEI-0477
Description
A lysine methyltransferase EZH2 (KMT63) inhibitor. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis.
Alias
DZNep; NSC 617989
Synonyms
DZNep; NSC 617989
CAS No.
102052-95-9
Product_Overview
A lysine methyltransferase EZH2 (KMT63) inhibitor
Targets
EZH2
Chemical Name
5R-?(4-?amino-?1H-?imidazo[4,?5-?c]pyridin-?1-?yl)-?3-?(hydroxymethyl)-?3-?cyclopentene-?1S,?2R-?diol
M.Wt
1202.6
Purity
>99%
Appearance
White solid
Solubility
DMSO and EtOH
Storage
-20 centigrade
Shipping Conditions
Gel pack
Handling
Protect from light and air
Usage
For Research Use Only! Not For Use in Humans.
